Lipid uptake and skin occlusion following topical application of oils on adult and infant skin.

نویسندگان

  • Georgios N Stamatas
  • Johanna de Sterke
  • Matthias Hauser
  • Otto von Stetten
  • André van der Pol
چکیده

BACKGROUND Topical application of oils and oil-based formulations is common practice in skin care for both adults and infants. Only limited knowledge however is available regarding skin penetration and occlusive potential of oils and common methods for measuring skin moisturization fall short when it comes to the moisturizing effect of oils. OBJECTIVE In this study we used in vivo confocal Raman microspectroscopy to test the efficacy of paraffin oil (mineral oil) and two vegetable oils in terms of skin penetration and occlusion. Petrolatum was used as a positive control. METHODS The products were applied topically on the forearms of nine volunteers and seven infants and Raman spectra were acquired before and at 30 and 90 min following application. Depth concentration profiles for lipid and water were calculated from the Raman spectra. Skin occlusion was assessed from the amount of stratum corneum (SC) swelling measured from the water concentration profiles. RESULTS The paraffin oil and the vegetable oils penetrate the top layers of the SC with similar concentration profiles, a result that was confirmed both for adult and infant skin. The three oils tested demonstrated modest SC swelling (10-20%) compared to moderate swelling (40-60%) for petrolatum. CONCLUSION These data indicate that there is no statistical difference between the paraffin oil and vegetable oils in terms of skin penetration and skin occlusion. The results for petrolatum show that in vivo confocal Raman microspectroscopy is sensitive and specific enough to measure both lipid uptake and skin occlusion events following topical application.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cosmetic Oils in comparison: penetration and occlusion of paraffin oil and vegetable oils

Introduction The skin represents an effective barrier to the environment, which can be treated and supported by the topical application of skin care products, such as oils or oil-based formulations. Skin care products with a high lipid content are recommended for the care of dry skin and inflammatory skin conditions. Pure oils (emollients) as well as oils integrated in diverse formulations are ...

متن کامل

Quantitative changes of mast cells following topical application of honey on third degree burns in rats

The purpose of present study was determination of number changes of mast cells in a honey treated experimental model of third degree burn. A third degree burn was made in 24 adult female rats by direct contact of skin with boiling water for 8 seconds. Rats were divided randomly into four groups. Group 1: Burns of this group remained untreated (control group). Groups 2 and 3: Burns of these grou...

متن کامل

Quantitative changes of mast cells following topical application of honey on third degree burns in rats

The purpose of present study was determination of number changes of mast cells in a honey treated experimental model of third degree burn. A third degree burn was made in 24 adult female rats by direct contact of skin with boiling water for 8 seconds. Rats were divided randomly into four groups. Group 1: Burns of this group remained untreated (control group). Groups 2 and 3: Burns of these grou...

متن کامل

In vivo investigations on the penetration of various oils and their influence on the skin barrier.

BACKGROUND The skin represents a potent barrier to the environment, which can be enhanced by the topical application of skin care products, such as oil and oil-based formulations by moisturizing the skin. METHODS The aim of this study was the investigation of the penetration behaviour of four vegetable oils and of paraffin oil into the stratum corneum by laser scanning microscopy. In addition...

متن کامل

Reduction of skin water loss in the newborn. I. Effect of applying topical agents.

The waterproofing effect of a number of creams, oils, and greases was examined by measuring water loss from adult skin before and after topical application. Creams had a high water content and were ineffective, oils produced a modest fall in water loss, but paraffin in grease form had a pronounced, sustained waterproofing effect. A paraffin mixture (80% soft, 20% hard paraffin (BP) was then app...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of dermatological science

دوره 50 2  شماره 

صفحات  -

تاریخ انتشار 2008